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J Dent Res 34(4): 470-477, 1955
© 1955 International and American Associations for Dental Research
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A TRACER STUDY OF THE EFFECT OF ACUTE AND CHRONIC EXPOSURE TO SODIUM FLUORIDE ON THE THYROID IODINE METABOLISM OF RATS

N. O. HARRIS D.D.S., M.SC.DENT.1 and R. L. HAYES PH.D.1

1 Dental Sciences Division, USAF School of Aviation Medicine, Randolph Air Force Base, Randolph Field, Texas, and Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tenn.

In a study designed to test the possible inhibitory effect of acute and chronic exposure to sodium fluoride on the uptake gradient and metabolism of iodine-131 by rat thyroids, the following facts were elicited:

1. Neither acute nor more chronic dosage of sodium fluoride inhibited the uptake of iodine-131 by the thyroid gland.

2. The transport of the iodine-131 through the acinar cell stage into the colloidal phase, and ultimate distribution to the blood plasma, were of equal magnitude, regardless of level of sodium fluoride used in the study.

Submitted on April 14, 1954






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