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J Dent Res 34(1): 4-11, 1955
© 1955 International and American Associations for Dental Research
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MORPHOLOGIC EFFECTS OF IRRADIATION ON THE SALIVARY GLANDS OF RATS

JAMES A. ENGLISH 1

1 Naval Medical Research Institute, Bethesda, Md.

Salivary glands of rats were examined sixteen hours to 100 days following application of 200 kv. x-ray radiation in doses of 1,000 and 1,500 r. A total of 162 rats were involved, seventy-two of them being used as littermate controls. Sufficient morphologic changes were observed in submaxillary salivary glands of animals sacrificed beyond the fifteen-day period to permit accurate separation of unmarked control and irradiated tissues. The changes consisted primarily of alteration in size, shape, and staining characteristics of nuclei of acinar cells. Changes were observed in other salivary glands, but were not characteristic enough to serve as invariable means of identification.

Submitted on November 26, 1953
Revised on December 29, 1953






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