EFFECT OF METHYLCHOLANTHRENE ON TOOTH GERM TRANSPLANTS: ADDITIONAL STUDIES

¹ Department of Pathology, Yale University School of Medicine, New Haven, Conn.

1. The present experiments extend and confirm previous observations.

2. There appeared to be less calcified enamel and dentin surviving over longer periods in the present experiments with methylcholanthrene-treated transplants.

3. Reactions with Masson stain showed that mostly epithelial tissues survived over periods of the experiment in methylcholanthrene-treated transplants.

4. Other staining reactions also demonstrated the presence of keratin.

5. Cells of the outer enamel epithelium that have persisted seemed to have attained some of the criteria for malignancy in instances where the transplant had been impregnated with methylcholanthrene, but the transplants did not become malignant.