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1 Department of Biochemistry and Nutrition, Schools of Dentistry and Medicine, the University of Southern California, Los Angeles, Calif.
Inhibition of both endochondral and periosteal bone formation was produced as a result of tryptophane deficiency. Regressive changes were observed at the end of three weeks in both the femur and alveolar process. In contradistinction to results on animals with dietary kidney damages produced by early choline deficiency, the disturbed growth of bone and dental tissue following early tryptophane deficiency can be corrected by subsequent supplementation of the deficient diet.
Submitted on April 21, 1953
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