A NEW APPROACH TO THE PROBLEM OF DENTAL CARIES CONTROL

¹ Chemistry Department, Northwestern University Dental School, Chicago, Ill.

A new approach to the problem of dental caries control based upon the retention of acid inhibitors in dental plaque has been suggested. Laboratory technics for the screening of compounds to conform to this theory were devised and performed on 381 compounds. Of these compounds, ten were found to be effective in the screening technics. Three of these were tested in vivo in dentifrices or mouthwashes and it was found that all three materially decreased the rate of acid formation on the tooth surface over long periods of time. Continued daily use of these compounds has shown that their efficiency is maintained. Two of these compounds, sodium N-lauroyl sarcosinate and sodium dehydroacetate, are now under clinical test to measure quantitatively their therapeutic effect on dental caries.

This article has been cited by other articles:

				L. S. FOSDICK Clinical Experiment on the Use of Sodium N-Lauroyl Sarcosinate in the Control of Dental Caries Science, June 1, 1956; 123(3205): 988 - 989. [PDF]