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J Dent Res 31(3): 421-427, 1952
© 1952 International and American Associations for Dental Research
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THE COMPARATIVE EFFECTS OF PENICILLIN, BACITRACIN, CHLOROMYCETIN, AUREOMYCIN, AND STREPTOMYCIN ON EXPERIMENTAL DENTAL CARIES AND ON CERTAIN ORAL BACTERIA IN THE RAT

ROBERT M. STEPHAN 1, ROBERT J. FITZGERALD 1, F. J. MCCLURE 1, M. RACHEL HARRIS 1, and HAROLD JORDAN 1

1 National Institute of Dental Research, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda 14, Md.

The antibiotics penicillin, bacitracin, aureomycin, Chloromycetin, and streptomycin were studied for their effectiveness in reducing experimental dental caries in the albino rat by adding them to a coarse particle diet. Penicillin at a concentration of 50,000 units per cent was most effective followed by bacitracin (5,000 units per cent), aureomycin, Chloromycetin, and streptomycin all at 50,000 micrograms per cent.

Studies of oral lactobacilli, streptococci, and coliforms revealed no consistent changes relatable to the caries picture.

Submitted on February 21, 1952






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