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J Dent Res 31(3): 398-411, 1952
© 1952 International and American Associations for Dental Research
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EARLY INFLUENCE OF METHYLCHOLANTHRENE ON TRANSPLANTED TOOTH GERMS: A HISTOPATHOGENIC STUDY

HAROLD S. FLEMING D.M.D., M.SC.1

1 The Department of Pathology, Yale University School of Medicine, New Haven, Conn.

1. Growth and differentiation of tooth germs, when transplanted with methylcholanthrene are retarded.

2. The presence of methylcholanthrene seemed to have a greater effect on the epithelial cells of the tooth germ than on the mesenchymal cells.

3. Keratin formation is generally present arising from both the inner (ameloblastic) and outer enamel epithelium.

4. Under these conditions peripheral cells of the outer enamel epithelium show aggressive characteristics and may invade adjacent structures.

5. The cells of the stratum intermedium move away from the basal side of the ameloblasts in chains or cords.

Submitted on March 31, 1952






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