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J Dent Res 31(1): 47-52, 1952
© 1952 International and American Associations for Dental Research
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MECHANISM OF ACTION OF SODIUM AZIDE ON THE GENUS CANDIDA

MARIE S. SLAWSON 1 and MARSHALL L. SNYDER 1

1 Department of Bacteriology, University of Oregon Dental School, Portland, Ore.

The effectiveness of sodium azide as a selective inhibitor of the yeastlike organisms of the saliva has been confirmed. The limit of duration of fungistasis of a 1:10,000 concentration of sodium azide in tomato-juice peptone agar has been established as 5 days at icebox temperatures. The mechanism of action has been shown primarily to be upon the iron-porphyrin pigments, the cytochromes and cytochrome oxidases, of the genus Candida.






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