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J Dent Res 31(1): 20-24, 1952
© 1952 International and American Associations for Dental Research
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INHIBITION OF ORAL SPIROCHETES BY ANTIBIOTIC AGENTS IN VITRO

ROBERT J. FITZGERALD 1 and EDWARD G. HAMPP 1

1 National Institute of Dental Research, National Institute of Public Health Service, Bethesda, Md.

A number of drugs were tested as inhibitors of growth of three strains of B. vincentii and three strains of small oral treponemes in vitro. Penicillin, bacitracin, chloromycetin, aureomycin, streptomycin, and tyrothricin inhibit growth of the oral spirochetes within concentration ranges that can be readily attained in the oral cavity. Sulpharsphenamine, hydrogen peroxide; and lupulon were also active. Under the test conditions employed notatin was relatively inactive.

Drug resistance could not be readily induced in the oral spirochetes and only one "spontaneously" resistant variant appeared. This was a small oral treponeme that was streptomycin resistant.

Submitted on June 12, 1951






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