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J Dent Res 29(2): 240-254, 1950
© 1950 International and American Associations for Dental Research
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FURTHER STUDIES ON THE EFFECT OF HUMAN SALIVA ON THE CHOLERA VIBRIO IN VITRO

CLARENCE E. DAWSON 1 and WILSON BLAGG 1

1 United States Naval Medical Research Unit No. 3, Cairo, Egypt

Under the conditions of the experiments, saliva from normal healthy individuals was found to have two antibacterial agents. These agents varied in their antibacterial specificity and exhibited both bacteriolytic and bacteriostatic properties against the cholera vibrio and several other organisms which were tested. The agents appeared to be components of salivary secretions and to be enzymic in nature. The results indicated that there was more constancy in the antibacterial action of saliva filtrates than that of whole saliva. Saliva filtrates from malnourished individuals and cholera patients revealed little or no antibacterial effect. This seems to indicate that the antibacterial properties of body secretions may play a dominant role in natural immunity to cholera infection.

Submitted on January 21, 1949
Revised on June 28, 1949






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