DENTAL CHANGES IN RATS ON A PURIFIED DIET DEFICIENT IN VITAMIN E
JENS JØRGEN PINDBORG L.D.S.1
1 National Dental College of Denmark, Department of Histology, and the Biological Laboratories of Medicinalco, Ltd., Copenhagen, Denmark
On a purified diet containing 0.1 per cent of succinylsulfathiazole and deficient in vitamin E, a depigmentation of the incisors and a series of histopathologic changes have been ascertained in 39 white rats. There was premature atrophy of the stratum papillare, marked edemas, and cyst formations. Rats treated with tocopherol did not exhibit these changes. The conclusion is drawn that the changes are attributable to a vitamin E deficiency.
Submitted on June 13, 1949
