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J Dent Res 29(1): 68-72, 1950
© 1950 International and American Associations for Dental Research
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THE TOOTH PULP AS AN ALGESIMETRY SITE

STANLEY C. HARRIS 1 and NORMA E. BRANDEL 1

1 Department of Physiology and Pharmacology, Northwestern University Dental School, Chicago, Ill.

The results of an experiment using the tooth pulp as the receptive site and 60-cycle induced current as a painful stimulus are analyzed and discussed.

The uniformity of premedication thresholds of two teeth in each of fourteen subjects, although high, is recognized as being due perhaps, to insensitivity of the instrument.

The reliability of threshold changes, after oral medication with codeine phosphate, 1 gr.; calcium lactate placeboes; aspirin, 5 gr., and a "dry" run is significant as determined by parallelism of response in pairs of teeth in the same head.

The fact that placeboes cause a significant increment of the tooth threshold indicated the importance of using placebo runs in any comparative study of analgesic drugs.

Submitted on April 18, 1949






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