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1 Departments of Periodontia and Bacteriology, Temple University, School of Dentistry, Philadelphia, Pa.
Carboxymethyl cellulose with petrolatum is a suitable vehicle for the topical application of penicillin in the treatment of Vincent's infection and similar infections of the oral mucosa. Preferably, it should contain 10,000 units of crystallin penicillin per gram.
The base alone has no antibacterial properties, but is not toxic and is compatible with crystallin penicillin. It can be safely stored at room temperature for at least 7 months.
The ointment will remain in situ for several hours, i.e., longer than necessary to exert its antibacterial action.
Its use does not obviate the necessity of proper prophylactic care in these cases.
Submitted on February 5, 1949
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