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J Dent Res 28(2): 124-137, 1949
© 1949 International and American Associations for Dental Research
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THE EFFECT OF WETTING AGENTS ON ORAL LACTOBACILLI

II. LOCAL AND SYSTEMIC TOXICITY IN MICE. TOXICITY VS. ANTIBACTERIAL ACTIVITY

FRANK E. WALTER D.D.S.1 and HARVE J. CARLSON Dr.P.H.1

1 Department of Microbiology and Pediatrics, School of Medicine, Western Reserve University, Cleveland, Ohio.

Sixty-nine surface-active agents were injected into mice to ascertain their relative local and systemic toxicity. The effect of these agents upon various microorganisms has been determined, and an attempt was made to correlate the toxicity with antibacterial activity. Data have been presented which indicates that some anionic surface-active agents are effective against gram-negative organisms. Certain general types of surface-active agents have indicated potentialities which merit further study.

Submitted on July 26, 1948






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