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J Dent Res 27(1): 34-40, 1948
© 1948 International and American Associations for Dental Research
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OBSERVATIONS ON INDUCED CARIES IN RATS

VI. SUMMARY RESULTS OF VARIOUS MODIFICATIONS OF FOOD AND DRINKING WATER

F. J. MCCLURE PH.D.1

1 Dental Research Section, Experimental Medicine and Biology Institute, National Institute of Health, Bethesda, Md.

The inhibitory effects of fluorine on induced rat caries are apparent at a level of 10 ppm in drinking water and are independent of any association with sodium sulfate, magnesium chloride, or free iodine in the water. Urea inhibited rat caries to a limited extent, when given in somewhat excessive quantities in the food and water. Nitrate added to the drinking water and food seemed consistently to inhibit experimental rat caries. Penicillin and iodoacetate have been reported from previous studies as markedly caries-inhibitory. The following substances gave no indication of any pronounced effect on induced rat caries: iron, copper, zinc, calcium chloride, sodium sulfate, magnesium chloride, potassium iodide, free iodine, potassium thiocyanate, and a strongly alkaline drinking fluid.

Submitted on October 15, 1947






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