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J Dent Res 26(5): 365-368, 1947
© 1947 International and American Associations for Dental Research
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PENICILLIN AND CARIES ACTIVITY

H. A. ZANDER 1 and B. G. BIBBY 1

1 Tufts College Dental School, Boston, Mass.

Minute amounts of penicillin inhibit acid formation in saliva-carbohydrate mixtures.

The capacity of saliva to ferment carbohydrates is eliminated for several hours following the use of a penicillin mouth wash.

Brushing penicillin mixtures on hamsters' teeth virtually prevents dental caries.

The above findings offer further evidence that the fermentation of carbohydrates by oral bacteria is important in the etiology of dental caries.

Submitted on July 23, 1947






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