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J Dent Res 24(1): 1-5, 1945
© 1945 International and American Associations for Dental Research
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EFFECT OF SUBANESTHETIC NITROUS OXIDE—OXYGEN MIXTURES ON PAIN SENSITIVITY OF THE TOOTH

ALFRED H. CHAMBERS 1 and GEORGE G. SCHULTZ 1

1 Department of Physiology and the School of Dentistry, University of Pennsylvania, Philadelphia, Pa.

1. The effect of subanesthetic nitrous oxide-oxygen mixtures on the pain sensitivity of the tooth was determined.

2. Sensation resulting from weak stimulation was found to be affected less by a given gas mixture than that from strong stimulation.

3. Analgesia sufficient for extraction was found to be produced by 60% nitrous oxide, and a significant degree of analgesia by mixtures containing not less than 30% to 40% nitrous oxide.

4. Maximum effect on pain sensitivity was reached within 2 to 6 minutes, depending on the gas mixture, and returned to normal within 5 to 10 minutes.

5. The application of these findings to clinical practice is discussed.

Submitted on October 24, 1944






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