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J Dent Res 22(4): 257-260, 1943
© 1943 International and American Associations for Dental Research
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THE MECHANISM BY WHICH IODOACETIC ACID INHIBITS EXPERIMENTAL DENTAL CARIES IN THE RAT

VERNON H. POWELL 1 and PETER P. DALE 1

1 Division of Dental Research, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

Experimental dental caries in the rat is inhibited by parenteral administration of iodoacetic acid to a degree comparable with its effectiveness when administered in the food or drinking water. Since iodoacetic acid diminishes caries activity in desalivated as well as normal animals, it appears that the mechanism of its action may be systemic.

Submitted on July 9, 1943






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