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J Dent Res 20(5): 457-463, 1941
© 1941 International and American Associations for Dental Research
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OBSERVATIONS ON INDUCED DENTAL CARIES IN RATS

II. THE EFFECT OF SUBCUTANEOUS INJECTION OF FLUORIDE

FRANCIS A. ARNOLD JR. 1 and FRANK J. MCCLURE 1

1 U. S. Public Health Service,1 Washington, D. C.

Subcutaneous injection of sodium fluoride produced no significant reduction in induced dental caries of rats.

The fluorine content of the enamel and dentin of the incisor and erupted molar teeth of rats was increased both by subcutaneous injection of sodium fluoride and by feeding water containing 10 ppm. F.

The observations on the injected rats would seem to rule out any systemic influence of fluorine on induced rat caries when the agent (F) is introduced during the post eruptive tooth period.

The results of this experiment indicate that although the fluorine content of the molar teeth of rats injected with sodium fluoride was increased, these teeth did not show increased resistance to caries.

Submitted on April 27, 1941






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