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J Dent Res 14(2): 69-91, 1934
© 1934 International and American Associations for Dental Research
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CHANGES IN TEETH FOLLOWING HYPOPHYSECTOMY

II. CHANGES IN THE MOLAR OF THE WHITE RAT

I. SCHOUR B.S., D.D.S., M.S., PH.D.1 and H. B. VAN DYKE PH.D., M.D.1

1 Chicago, Illinois

Effects of hypophysectomy on molars of white rats have been studied in twenty-two completely hypophysectomized animals (63 to 459 days after operation) and fifteen litter-mate controls in respect to rate of eruption, and gross and microscopic alterations. The findings were retarded eruption; persistence of juvenile characteristics, shorter root lengths, and wider pulp-chambers, pulp canals and apical foramina; histopathologic changes; disturbances in calcification; vascular disturbances.

The changes are progressive. The actual conditions in a given case naturally depend on the time elapsing between operation and death.

Replacement therapy produced more or less complete recovery of the histologic changes in molars, depending on number of phyone injections.

The data throw interesting light on various phases of the growth and eruption processes of teeth.






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