Figure 1. Tissue factor induction by oral streptococci in a transwell system. PBMC (10⁶) were stimulated with 4 strains of oral streptococci (10⁷) in 200 µL enriched RPMI without antibiotics in transwell inserts. The up-regulation of endothelial TF activity in 6 hrs was measured with the factor Xa assay (mU/mL). Data from 4 independent experiments were analyzed with ANOVA. *Significant increase of TF activity when compared with PBMC control by Tukey’s HSD (p < 0.005). The vertical bars represent standard errors.