Figure 1. Unbalanced remodeling of the skeleton in post-menopausal osteoporosis because of excessive osteoclastic bone resorption and reduced capacity of osteoblasts to refill the resorption lacunae results in a decreased amount of bone tissue, loss of trabecular bone architecture, and, eventually, increased risk for fracture (compare normal bone in A and bone from an osteoporotic patient in B) [reproduced with permission of the American Society for Bone and Mineral Research from Dempster et al., J Bone Miner Res 1:15–21, 1986 ]. Unbalanced remodeling of the jawbones close to a chronic inflammatory process in the gingiva leads to loss of bone surrounding the roots of the teeth, and eventually to increased mobility and loss of teeth (C). (magnification not defined)