Figure 1. Dose-dependent effects of simvastatin on KB cells. (A) Cellular expression of IL-6 and IL-8 is shown in cultures after treatment with the indicated concentrations of simvastatin for 7 hrs, and/or IL-1 (1 ng/mL) for the last 5 of these hrs. Data are expressed as means ± SD (n = 4). *P < 0.01 and **P < 0.001 vs. control (treated with IL-1). (B) Evaluation of cytotoxicity from simvastatin according to release of LDH into medium was carried out after 24 hrs of culture. LC, low control (medium alone); HC, high control (1% Triton X100).