Figure 4. The in vivo anti-metastatic effects of silibinin. After subcutaneous implantation of LLC cells, C57BL/6 mice were treated with corn oil or silibinin as described in MATERIALS & METHODS, and then analyzed for the number of lung metastases (A), the growth of tumors (B), the weight of the primary tumor (C), and body weight (D). The values represent the means ± SD. Comparisons were performed by Student’s t test (*P < 0.05).