Figure 4. The alveolar bone from ligated (8 days) rats demonstrated alveolar bone resorption (a). Rosiglitazone treatment suppressed alveolar pathology in the rats’ alveolar bone (b). A significant increase in the distance between the cemento-enamel junction and the alveolar crest at the mediolingual root of the first molar was observed in ligature-treated rats. Rosiglitazone treatment significantly reduced the increase in the distance between the cemento-enamel junction and the alveolar crest (c). The Fig. is representative of at least 3 experiments performed on different experimental days. Data represent the data from 20 counts obtained from the gingivomucosal tissue of each treatment group. *P < 0.01 vs. non-ligated. °P < 0.01 vs. ligated.