Figure 4. Both LRAP and P172 promote migration of cementoblast/periodontal ligament cells. (A) Amelogenin-KO (KO) cementoblast/periodontal ligament cells exhibited a reduced cell migration rate. (B) Addition of the conditioned medium from the three-day cultures of wild-type cementoblast/periodontal ligament cells increased the migration rate of amelogenin KO-cementoblast/periodontal ligament cells. (C,D) Increased cell migration rates in the WT and amelogenin KO-cementoblast/periodontal ligament cells cultured with 100 ng/mL LRAP (C) and P172 (D) for 12 hrs. Data are expressed as the mean ± SD (n = 3) of the µm distance covered by cementoblast/periodontal ligament cells. *P < 0.05 vs. day 0 and **P < 0.01 vs. day 0.