Figure 3. Both LRAP and P172 induce the proliferation of cementoblast/periodontal ligament cells. (A) Amelogenin-KO (KO) cementoblast/periodontal ligament cells showed reduced proliferation. **P < 0.01. (B,C) Increased proliferation rate of KO cementoblast/periodontal ligament cells treated with either LRAP or P172. Amelogenin-KO cementoblast/periodontal ligament cells were cultured with various concentrations of LRAP (B) or P172 (C) for 1, 3, and 5 days. *P < 0.05 vs. day 0, **P < 0.01 vs. day 0, ^#P < 0.05 vs. 0 ng/mL group, and ^##P < 0.01 vs. 0 ng/mL group. (D,E) Wild-type (WT) cementoblast/periodontal ligament cells were cultured with various concentrations of LRAP (D) or P172 (E) for 1, 3, or 5 days. Data are expressed as the mean ± SD (n = 3). *P < 0.05 vs. day 0, **P < 0.01 vs. day 0, ^#P < 0.05 vs. 0 ng/mL group, and ^## P < 0.01 vs. 0 ng/mL group.