Figure 2. LRAP inhibits the osteoclastogenic pathway. (A,B) RANKL and osteoprotegerin (OPG) mRNA levels as measured by RT-PCR analysis of total RNA extracted from cementoblast/periodontal ligament cells treated either with 100 ng/mL of LRAP (A) or P172 (B) for 0, 12, 24, 48, or 72 hrs. GAPDH was used as the internal control. WT, wild-type mice; KO, amelogenin-KO mice.