Figure 5. Bone metabolic activity of animals implanted with control (no cells) or adipose-derived adult stromal (ADS) cell-seeded scaffolds, as determined by radiolabeled methylene diphosphonate incorporation overlaid with micro-CT images. For each time-point, the top row displays the micro-CT scan, the middle row displays the metabolic activity, and the lower row displays the overlaid composite of metabolic activity and micro-CT scan. For all columns at each time-point, the left column is the x axis, the middle column is the y axis, and the right column is the z axis. For orientation, we have marked the defect with a yellow arrow for the three views of the micro-CT image. The location of the defect does not change between 2 and 12 weeks. Bone scan intensity is indicated in color on the left axis of the image, with white and red indicating the highest value and black and blue indicating lowest value. This Fig. originally appeared in Cowan et al.(2004) and is reproduced here with permission from the Nature Publishing Group (http://www.nature.com/).