Figure 3. Fibroblasts from healthy patients (HP) who never received any treatment with CsA. TEM micrographs of FCS-deprived fibroblasts (3a; UN = untreated cells; HC = heterochromatin; IC = interchromatin; N = nucleolus; bar = 0.5 µm) and CsA-treated ones (3b; +CsA; bar = 0.5 µm), both revealing scarce labeling related to interchromatin domains. (c) Quantitative evaluation of the nuclear labeling density was performed with the Mann-Whitney U test (UN; n = 10) (+CsA; n = 10). Values are the means of examined cases ± SD. No significant difference was observed (power = 0.71).