Figure 4. Family 2. Panel A shows the pedigree, and panel B shows DNA sequencing chromatograms of the intron 6/exon 7 splice junction. Arrows indicate the position of the A to C transversion and the corresponding wild-type (wt) sequence (IVS6-2A>C). Panels C through F show intra-oral photographs and a panorex of the proband at age 12.5. Panels G through I show intra-oral photographs and a panorex of the the proband’s 11-year-old brother. Panel J shows an oral photograph of the remaining mandibular anterior teeth of the proband’s mother, taken at age 32.