Figure 3. Family 1. Panel A shows the pedigree, and panel B shows DNA sequencing chromatograms of the exon 8/intron 8 splice junction. The site of the frameshift mutation and the corresponding wild-type (wt) sequences are indicated by arrows (g.8344delG). Panels C and D show a frontal photograph and a panorex radiograph for the proband taken at ages 11 and 6, respectively. Panels E through H show intra-oral photographs and a panorex radiograph taken at age 19. The upper anterior teeth were treated endodontically and restored with composite resin restorations.