Figure 4. Schematic representation of the molecular events occurring during reparative dentinogenesis. (A) Illustration of the reparative dentin area showing expression of AP-1, nestin, N-cadherin, and connexin 43 (Cx43) in odontoblasts, and of Notch2 in sub-odontoblastic cells. (B) Diagram showing the sequence of molecular events during tooth repair. Shorter arrows indicate early events, longer arrows late events. FGF and TGFß molecules that are released from dentin and pulp cells activate wound healing. Abbreviations: d, dentin; o, odontoblasts; p, pulp; rd, reparative dentin; soc, sub-odontoblastic cells.