Figure 3. Photomicrographs showing taste papillae. Rich VR1-immunoreactive fibers in taste papillae: fungiform (A,B), circumvallate (D,E,F), foliate (G,H,I,J), and Geschmacksstreifen (K,L). CGRP immunoreactivities in fungiform papilla (C). Many VR1-positive fibers surround the furrows of the circumvallate and foliate papillae, forming plexuses (double arrows). Arrowheads indicate nerve fibers penetrating the apical and trench wall epithelia. Occasional fibers enter taste buds or pores (arrows). Conspicuous VR1-positive nerves in the boundary area just above the taste buds (F,I). Low-power micrographs showing VR1 expression in the dorsal (A,D), lateral (G), and ventral epithelium (K) (asterisks). Scale bars: A,D,G,K = 50 µm; B, C,E,F,H,I,J,L = 20 µm.