Figure 1. Activation of syndecan-1 during wound healing. (A) Syndecan-1 immunohistochemical staining (brown) of intact skin and (B) tongue mucosa. (C) Induction of syndecan-1 staining is seen 24 hours after wounding occurs in skin and (D) 12 hours after wounding occurs in oral mucosa during the early proliferative phase. (E) Seven days after being wounded, the skin is remodeling, and strong syndecan-1 staining is detected, similar to that in (F) a mucosal wound five days after being wounded. * = wound site.