Figure 4. Cbfa1 gene expression is significantly (P < 0.05) increased in UMR (A) and RCOB (B) osteoblast culture models grown on roughened implant surface microtopographies as demonstrated with Real Time PCR analysis. BSPII gene expression increased in UMR cultures (C), but was reduced in RCOB cells (D) cultured on rough as compared with grooved implant surfaces. n = 9/group; mean ± SD.