Figure 2. BMP-7-transduced oral human keratinocyte (A,B) and gingival fibroblast produced ossicles (C,D) and secreted BMP-7 in vivo. Specimens were developed for immunohistochemical analyses with anti-BMP-7 (A,C), control non-immune IgG (B,D), and counterstained with hematoxylin. The ossicles were harvested and prepared for analysis 3 wks after implantation. Bar = 700 µm.