Figure 3. CRAMP protein is expressed in the submandibular (salivary) gland, and oral mucosa. CRAMP protein in submandibular glands of adult mouse (A), E-17 embryonic mouse (B), newborn Day-4 mouse (C), and palatine minor salivary gland of the newborn (G). Newborn gingiva (H) and tongue (I, lower layer) also show CRAMP expression. In newborn palatal mucosa, CRAMP is located in the basal cell layer and a few suprabasal cells (I, upper layer). For negative controls, pre-immune rabbit IgG (D-F, J-L) was used. Original magnifications: x400.